A motorist was killed last weekend in a head-on crash in Palmdale.

Sergio Valencia, 40, of Palmdale was fatally injured in the crash, which occurred about 10:40 p.m. Oct. 21 on 50th Street East north of Avenue Q, the California Highway Patrol reported.

According to the CHP, Valencia was driving a 1997 Honda Civic south on 50th Street East when “for an unknown reason’’ his car went over the double yellow lines and crashed head-on with a 2016 Honda Fit that was northbound.

The driver and passenger in the Honda Fit were taken to a hospital for treatment of moderate to major injuries, the CHP reported.

“Alcohol and drugs (are) not suspected to be a factor in this collision,’’ the CHP said.

Following the crash, 50th Street East was closed in the area until about 3:30 a.m. Monday while an investigation was conducted, the CHP reported.